Earth Bound Zero is a console role-playing game (RPG) developed by Ape, Inc., Pax Softnica and Nintendo Tokyo R&D Products and published by Nintendo for the Family Computer (Famicom) video game console. It was designed and directed by Shigesato Itoi and produced by Shigeru Miyamoto, with music by Keiichi Suzuki and Hirokazu Tanaka. It is the first game in the Mother video game series (otherwise known as the EarthBound series), and was never released outside of Japan.

EggerLand is a Puzzle game, developed and published by Hal, which was released in Japan in 2000.

Egypt is a puzzle game released for the Family Computer in 1991 by Human Creative. It was released only in Japan. It is an object elimination type puzzle game. A player controls a spherical jewel, and jumps from tile to tile. Stepping on an arrow shifts a row or column in the direction of the arrow. Place two or more of the same object next to each to clear away objects. Clear all objects from a level to beat the level.

Elevator Action was released on the Wii Virtual Console download service on March 5th, 2007. It costs 500 points and can be played with the normal Wii Remote controller. It was rated E for Everyone by the ESRB. It should be noted that this is the first version of the game to be rated by the ESRB.

Challenge eight quirky characters to three races apiece in Eliminator Boat Duel for NES. Each timed course is viewed primarily from an overhead perspective as you steer around hazards, such as whirlpools and sharks, while using turbo boosts and jumps to outmaneuver your rival.

Help jump your Evel Cownievel over the tractors to score your points. Make sure Evel Cownievel lands on the ramp to score.

Evert and Lendl Top Player's Tennis is a Tennis game, developed by Asmik Ace Entertainment, Inc and published by Asmik Corporation of America, which was released in 1990.

Exed Exes is an arcade game that was released in 1985 by Capcom. It is a vertically-oriented scrolling shooter. It was originally released in North America as Savage Bees (full title: Attack of the Savage Bees) by Memetron (licensor to the game).

Exerion is a vertical shoot 'em up released by Jaleco in 1983 and licensed to Taito for distribution on the United States. Exerion is a shoot 'em up game featuring parallax effects and inertia simulation, something notable for 1983. The player travels around strange scenarios shooting aliens. The player has two types of guns: fast single shot (limited) or slow double shot (unlimited).